Carboxamide, sulfonamide and amine compounds, pharmaceutical compositions containing them and their use in the preparation of medicaments for treating metabolic disorders

摘要

Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R4, E, T, n and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.