Use of GTF21 mutations in the prognosis of thymic cancers

摘要

Disclosed are methods of determining the prognosis of thymic cancer in a subject comprising detecting a mutation in the general transcription factor IIi (GTF2I) genetic sequence or protein. The presence of a GTF2I mutation indicates that the thymic cancer is indolent.

主权项

1. A method for detecting a GTF2I mutation in a tumor, the method comprising:
obtaining genetic material from the tumor; assaying the genetic material; and detecting a mutation in at least one copy of GTF2I genetic sequence, wherein the mutation is selected from the group consisting of: (a) the T>A mutation at position 75,041 of SEQ ID NO:1; (b) the T>A mutation at position 1208 of SEQ ID NO: 3; (c) the T>A mutation at position 1211 of SEQ ID NO: 4; (d) the T>A mutation at position 1271 of SEQ ID NO: 5; (e) the T>A mutation at position 1148 of SEQ ID NO: 6; and (f) the T>A mutation at position 1205 of SEQ ID NO: 7.