Alkoxyacetamido-adamantanes - with virustatic props

摘要

Aminoadamantane derivatives of formula (I) are new (where R1 is H or CH3 and Y is the residue -(CH2)x-H in which x is 1-11). This is an addition to 1941218. (I) have excellent virustatic properties, e.g. against influenza and parainfluenza viruses. Results of in vitro tests are given in the specification. (I) are prepared by reacting a corresponding N-haloacetyl-aminoadamantane with an equimolar amount of the alkali metal alcoholate of Y-OH in the presence of excess Y-OH at elevated temperature, removing the resulting alkali metal halide and the excess Y-OH, and opt. purifying the product by distillation or recrystallization.