BENZODIAZEPINE DERIVATIVES

摘要

7-Alkanoylbenzodiazepines -anticonvulsants, muscle relaxants and sedatives Cpds. have formula:- (where B is methylene or carbonyl, R1 is hydrogen or lower alkyl; R2 is hydrogen, halogen or nitro and R3 is hydrogen or lower alkyl. 7-acetyl-5-o-furophenyl-2,3-dihydro-1-methyl-1H-1,4-benzodiazepin- e. They may be prepared by reacting a 5-diazonium salt with an aldehyde oxime on semicarbazone to give the benzodiaze-pin-5-ylcarbonyl oxime or semicarbazone which is then hydrolysed.