Benzodiazepine derivatives and production thereof

摘要

The present invention relates to 1,4-benzodiazepine derivatives represented by the general formula: WHEREIN R1 is a member selected from the group consisting of hydrogen, halogen, nitro, and trifluoromethyl group, R2 represents a member selected from the group consisting of hydrogen, C1 - C6 alkyl, C2 - C6 alkenyl or alkynyl, C3 - C6 cycloalkyl- C1 - C4 alkyl, and substituted or unsubstituted hydroxy- C1 - C4 alkyl group, R3 represents alkyl group having 1 - 4 carbon atoms, EACH OF R4 and R5 represents a member selected from the group consisting of hydrogen, halogen, C1 - C4 alkyl, and trifluoromethyl group, AND Z represents (WHEREIN EACH OF R6 and R7 represents hydrogen, C1 - C6 alkyl, C2 - C6 alkenyl or alkynyl, C3 - C6 cycloalkyl- C1 - C4 alkyl, substituted or unsubstituted hydroxy, substituted or unsubstituted hydroxy- C1 - C4 alkyl, or substituted or unsubstituted amino, or substituted or unsubstituted amino- C1 - C4 alkyl group), -CN, -R8 (wherein R8 represents C1 - C10 alkyl, or C1 - C4 alkoxy- C1- C4 alkyl group), -OCH2-R9 (wherein R9 represents hydrogen, C1 - C6 alkyl, C2 - C6 alkenyl or alkynyl, phenyl, or phenyl- C1 - C4 alkyl group), OR -C 3BOND C-R10 (wherein R10 represents hydrogen, or C1 - C6 alkyl groups which may be substituted by a secondary amino group or by a substituted or unsubstituted hydroxy group).