摘要 |
A method of diagnosing central nervous system injuries such as acquired brain injury (ABI) and/or acquired spinal cord injury (ASI), including mild TBI (concussion or blast wave), mild ASI (contusion, stretch or partial cord transection), non-TBI brain injury and/or non-TSI spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix; and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of CNS injuries and a predetermined set of profiles of controls to determine if the subject has a CNS injury. |
申请人 |
LONDON HEALTH SCIENCES CENTRE RESEARCH INC. |
发明人 |
FRASER, Douglas Dale;BARTHA, Robert;BROWN, Arthur;STEWART, Tanya Charyk;DALEY, Mark;DEKABAN, Greg A.;DOHERTY, Timothy;FISCHER, Lisa;HOLMES, Jeff;MENON, Ravi;RUPAR, Tony |