| 发明名称 |
Composition and Method for Therapeutic Agent Delivery During Pregnancy |
| 摘要 |
A composition including an elastin-like polypeptide (ELP) coupled to a therapeutic agent is provided. The ELP comprises at least about 5 repeats of the amino acid sequence VPGXG. Further provided is a method of using the composition for therapeutic agent delivery during pregnancy to reduce the amount of the therapeutic agent crossing a placenta in a pregnant subject. The method includes administering to the pregnant subject an effective amount of the composition comprising the ELP coupled to the therapeutic agent. |
| 申请公布号 |
US2016297868(A1) |
申请公布日期 |
2016.10.13 |
| 申请号 |
US201414917460 |
申请日期 |
2014.10.01 |
| 申请人 |
UNIVERSITY OF MISSISSIPPI MEDICAL CENTER |
发明人 |
Bidwell, III Gene L.;George Eric M. |
| 分类号 |
C07K14/78;C07K7/08;A61K38/17;C07K14/47;A61K38/18;C07K14/49 |
主分类号 |
C07K14/78 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of delivering a therapeutic agent to a pregnant subject, comprising administering to the pregnant subject an effective amount of a composition comprising an elastin-like polypeptide (ELP) coupled to a therapeutic agent, wherein the ELP includes an amino acid sequence having at least about 5 repeats of the amino acid sequence VPGXG (SEQ ID NO: 1), and wherein the composition reduces the amount of the therapeutic agent crossing the placenta in the pregnant subject. |
| 地址 |
Jackson MS US |
