N-(2-cyano-3-forylamino-3-hydroxyallylidene)hydrazides - derived from heterocyclic acids, with xanthinoxidase inhibiting activity

摘要

N-(2-cyano-3-formylamino-3-hydroxyallylidene) hydrazides of formula (I), and their tautomers and salts, are new: (where alk is 1-5 C alkylene, pref. CH2 or CH2CH2; n = 0 or 1; R3 is an opt. hydrogenated heteroaromatic residue, opt. substd.). Cpds. (I) are xanthinoxidase inhibitors and are esp. useful for treating gout; their toxicity is lower than that of allopurinol and they can be used in lower doses, e.g. 50-500 mg compared with 100-800 mg. They also have antiarrhythmic activity and can be used to treat coronary insufficiency, and can also be used as intermediates for 4(1H)-pyrimidiones with similar activity (DT-2410650).