| 摘要 |
<p>The preparation of a range of N-fluorinated amides and amines by treatment of an acid amide with a hypofluorite in which the fluoroxy group is bonded to an inert electron attracting group is described, suitable fluorinating agents including fluoroalkyl hypofluorites such as trifluoromethyl hypofluorite. Primary and secondary amides are converted into N-monofluoro amides, which may be cleaved hydrolytically to yield N-monofluoroamines; N-monofluoro carboxamide products may also be cleaved fluorolytically, e.g. by treatment with excess hypofluorite, to yield N,N-difluoroamines. Tertiary amides may be converted directly into N-fluorinated amines, this last conversion preferably being effected under acid conditions.</p> |
