3,20-Dioxo-17-alpha-hydroxy-4-pregnene 21-acid derivs - as local antiinflammatory agents having long lasting and rapid acting effects

摘要

Pregnane 21-acids of formula (I) (where x is H, F or Me; Y is H, F or Cl; Z is CH2, CHOH, beta-AcylOCH, when Y is Cl, beta-ClCH2 or beta-FCH2: V is -CH2-, MeCH or -CH2=Cl-2, R is H or acyl; R2 is H, a cation or a residue of an alcohol, and ------ is an opt. double bond). are anti inflammatory agents for local administration, having rapid initial action, a high inversion intensity and long lasting effect.