PROCESS FOR THE PRODUCTION OF 21-METHOXY-11-BETA-PHENYL-19-NOR-PREGNA-4,9-DIENE-3,20-DIONE DERIVATIVES

摘要

The present invention relates to a process for the synthesis of compounds of formula (I),;;wherein the meaning of R is dimethylamino or acetyl group, using the compound of formula (III) or (IV), wherein the meaning of R′ is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, as starting material and methoxymethyl lithium as reagent.;

主权项

1. Process for the synthesis of compound of formula (I) wherein the meaning of R is dimethylamino or acetyl group, characterized by a) reacting the compound of formula (III) or (IV), wherein the meaning of R′ is dimethylamino or 2-methyl-1,3-dioxan-2-yl group, with methoxymethyl lithium, b) removing the protective groups of the so obtained intermediate, c) acylating the hydroxyl group in position 17 of the so obtained compound of formula (II).