| 主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof, wherein:
R1 is Formula (i) represents a single or double bond, provided that no more than one double bond to X2 exists;X1 is —O—, —S—, —N(R3), or —C(H)(R3)— when a single bond exists between X1 and X2; orX1 is —N═ when a double bond exists between X1 and X2;X2 is —N═, —C(R6)═, or ═C(R6)—N═ when a double bond exists between X2 and X1 or X2 and X3; orX2 is —N(R6)—, —C(R6)2—, or —C(H)(R6)—C(H)(R6)— when single bonds exist between X2 and both X1 and X3; orX3 is —O—, —S—, —N(R3)—, or —C(H)(R3)— when a single bond exists between X3 and X2; orX3 is —N═ or —C(R3)— when a double bond exists between X3 and X2;provided that at least one of X1, X2, or X3 is selected from —N═ or —O—;G is H, halo, alkyl optionally substituted with 1-3 halo, or alkoxy optionally substituted with 1-3 halo;Q1 is N or C(R6);Q2 is N or C(H);Q3 is N or C(R8);each R6 is independently H, halo, amino, C1-C3 alkyl optionally substituted with 1-3 halo, or C1-C3 alkoxy optionally substituted with 1-3 halo;R2 is L-Z—(R4)n;n is 1, 2 or 3;L is absent, alkynylene, —O-alkylene, —C(O)—, C(O)-alkylene-, -alkylene-C(O)—, —N(R7)—C(O)—, —C(O)—N(R7)—, —S(O)2—, —N(R7)—S(O)2—, or —S(O)2—N(R7)—;Z is absent, arylene, heteroarylene, or heterocycloalkylene; wherein Z is optionally substituted with halo, hydroxy, alkyl optionally substituted with 1-3 halo, or alkoxy optionally substituted with 1-3 halo;each R3 is independently H, amino, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, alkyl, alkoxy, hydroxyalkyl, alkoxy, arylalkyl, heteroarylalkyl, or alkylsulfonyl, wherein R3 is optionally substituted with 1-3 R5 groups;each R4 is independently H, alkyl, halo, alkoxy, hydroxy, cyano, C(O)(R7), cycloalkyl, heterocycloalkyl, heteroaryl, heterocycloalkylsulfonyl, —N(R8)(R8), —N(R7)—S(O)2-alkyl, —N(R7)—S(O)2-alkenyl, —S(O)2—N(R7)(R7), —N(H)—S(O)2-cycloalkyl, —S(O)2-cycloalkyl, cycloalkylamino, cycloalkylalkoxy, —N(H)—C(O)-alkyl, cycloalkylaminocarbonyl, carboxyl, carboxylalkyl, or carboxylalkoxy, wherein each alkyl, alkoxy, cycloalkyl, heteroaryl, or heterocycloalkyl moiety of R4 is optionally substituted with 1-3 groups independently selected from C1-C4 alkyl, C1-C3 alkoxy, cyano, hydroxy, oxo or halo;each R5 is independently halo, alkyl, alkoxy, cyano, —N(H)(R7), hydroxy, alkylsulfonyl, alkylcarbonyl, or alkoxycarbonyl, wherein each alkyl moiety of R5 is optionally substituted with 1-3 groups independently selected from halo, hydroxy, alkyl optionally substituted with 1-3 halo, or alkoxy optionally substituted with 1-3 halo;each R7 is independently H, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocycloalkyl, alkyl, alkoxy, hydroxyalkyl, amino, hydroxy, arylalkyl, heteroarylalkyl, or alkylsulfonyl; andeach R8 is independently H or alkyl. |
