| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to a biologically degradable and/or absorbable silica gel materials, used in medicine for creation of cellular complex, tissue or body with fibrous matrix of polysilicic acid. In the presence of a water-soluble solvent for at least 16 hours at a temperature from 0 to 80 °C and initial pH from 0 to ≤ 7 acid catalysis reaction of hydrolytic condensation of one or more silicon compounds of formula SiX4, in which the radicals X are identical or different and are hydroxy, hydrogen, halogen, amino, alkoxy, acyloxy, alkylcarbonyl and / or alkoxycarbonyl and are derived from alkyl radicals, optionally substituted straight-chain, branched or cyclic radicals having 1 to 20 carbon -atoms, preferably having 1 to 10 carbon atoms, constitute, and may be interrupted by oxygen or sulfur atoms or by amino groups. By a subsequent evaporation phase solution having a viscosity in the range of 0.5 to 2 Pa · s at a shear rate of 10 s -1 at 4 °C is formed. This solution is subsequently cooled and is subjected to a kinetically controlled ripening, in which a homogenous one-phase sol is formed.EFFECT: sol is used, as a spinning material for making biologically resorbable and/or biologically degradable fibers and nonwovens or as material for making biologically absorbable and/or biologically active powder (s), monolith (s) and/or coating (s) in medicine and /or medical equipment, primarily for treating and/or wound healing.13 cl, 2 ex, 2 tbl, 4 dwg |
