Triazolothienodiazepine compounds

摘要

Triazolothienodiazepine compounds of the formula; WHEREIN X is a member selected from the group consisting of a hydrogen atom, a methyl group, a methoxy group and a trifluoromethyl group; each of R1 and R2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R1 and R2 together can form a tetramethylene group, i.e.-(CH2)4-; R is a member selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, -CONHR3 (R3 being an alkyl group having 1 to 4 carbon atoms) and -alk-N(R 4)(R5) (each of R4 and R5 being a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R4 and R5 and N can form a heterocyclic ring; and alk being an alkylene group having 2 to 4 carbon atoms); and Z is a member selected from the group consisting of an oxygen atom and a sulphur atom; and the pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds are useful as minor tranquillizers (anti-anxiety drugs), sleep inducers, and anti-epileptics.