摘要 |
Racemic or optically-active prostaglandin E1 is synthesized from racemic or optically-active precursors in good yield at the various steps from 3 alpha , 6,7,7 alpha -tetrahydro-4-methyl-2-oxo-1 beta -indaneheptanoic acid methyl ester proceeding through 2 alpha -(2-carboxyethyl)-3 beta -hydroxy-5-oxo-1 beta -cyclopentaneheptanoic acid methyl ester, delta -lactone, 5-cyclic ethylene acetal, 2 alpha -(2-carboxy-2-formylethyl)-3 beta -hydroxy-5-oxo-1 beta -cyclopentaneheptanoic acid methyl ester, delta -lactone, 5-cyclic ethylene acetal, 2 alpha -(2-carboxy-2-oxoethyl)-3 beta -hydroxy-5-oxo-1 beta -cyclopentaneheptanoic acid methyl ester, delta -lactone, 5-cyclic ethylene acetal, and 3 beta -hydroxy-2 alpha -(3-oxo-1-octenyl)-5-oxo-1 beta -cyclopentaneheptanoic acid methyl ester, 5-cyclic ethylene acetal.
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