Multi-scale wrinkles for functional alignment of stem cells and cardiac derivatives

摘要

Provided are methods of preparing a biocompatible textured surface on a thermoplastic material comprising treating the material with a plasma and subsequently shrinking the substrate to induce formation of textures. The textured surfaces are useful in one aspect, to align cells such as stem cells.

主权项

1. A plurality of cells aligned on nanoscale wrinkles or textures on a surface of a thermoplastic material, wherein the wrinkles or textures are prepared by a method comprising:
treating a surface of a thermoplastic material with a plasma to increase the stiffness of an outer layer of the surface relative to a subsurface layer, constraining two opposite sides of the plasma-treated thermoplastic material, and shrinking the constrained plasma-treated thermoplastic material under conditions to buckle the outer layer to form a surface with nanoscale wrinkles or textures relative to the subsurface layer of the material.