| 摘要 |
NEW MATERIAL:The compound of formula I (X is cis or trans-vinylene or ethylene; R<1> is H or 1-12C alkyl; R<3> is 1-10C alkyl; the double bond between 3- and 4-C atoms is trans or cis, or their mixture; the wavy line has alpha- or beta-configuration). EXAMPLE:9-Oxo-11alpha,15alpha-dihydroxy-16,16-dimethylprosta-trans- and cis-3-trans-13- dienoic acid methyl ester [16,16-dimethyl-trans- and cis-DELTA<3>-PGE1 methyl ester]. USE:Useful as oxytocic, abortifacient, fertility improver, estrus regulative, contraceptive, emmenagogue, etc. PREPARATION:The compound of formula I (X is Y and R<1> is R<7>) can be prepared by hydrolyzing the OR<8> group of the compound of formula II (Y is cis- vinylene or ethylene; R<7> is 1-4C alkyl; R<8> is 2-tetrahydropyranyl) to hydroxyl group. |
