| 摘要 |
<p>Novel analogues of prostanoic acids, which have the accompanying formula I, in which the symbols R1 to R3 have the meaning given in Patent Claim 1, are prepared by removing the tetrahydropyranyl ether protective group and the ketal grouping simultaneously or successively from an appropriately substituted 3-tetrahydropyranyloxy- 1,5-dioxaspiro compound. The corresponding compounds in which, instead of the keto group in the cyclopentyl radical, hydrogen and a hydroxy group are present, are obtained by reduction with a complex metal hydride. The compounds can then be converted into their physiologically tolerable salts or esters. The compounds are distinguished, even in the form of their epimer mixtures, by a good general spasmolytic, in particular bronchodilatory, action. They additionally have a hypotensive action and can also be employed in some cases in gastrointestinal disorders. <IMAGE></p> |
