发明名称 |
PROCESS FOR PRODUCING 7-ACYLAMIDO-3-BRACKET-1,2-DISUBSTITUTED-I,3,4-TRIAZOL-5-YL-THIOMETHYL-BRACKET CLOSED-3-CEPHEME-4-CARBOXYLIC ACID DERIVATIVES |
摘要 |
1467217 Cephalosporins MEIJI SEIKA KAISHA Ltd 19 June 1975 [20 June 1974] 26071/75 Heading C2C The invention comprises novel antibiotic compounds (I) and (I<SP>1</SP>) wherein R<SP>1</SP> is a phenyl group, a 2-thienyl group or a phenoxy group; R<SP>2</SP> is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms which may be substituted with a phenyl group, an alkoxy group having 1 to 4 carbon atoms or a halogen atom, or a phenyl group which may be substituted with one or two groups selected from a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R<SP>3</SP> is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms which may be substituted with a monoalkylamino group having 1 to 4 carbon atoms in the alkyl moiety thereof, a dialkylamino group having 1 to 4 carbon atoms in each alkyl moiety thereof, a halogen atom or a phenyl group which may be substituted with one to three groups selected from a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms and an alkoxy group having 1 to 4 carbon atoms; R<SP>4</SP> represents an alkyl group having 1 to 4 carbon atoms; A has up to 15 carbon atoms and represents a straight or branched chain alkylene group, a straight or branched chain alkadienylene group or a phenylene group, and n is 0 or 1; or a salt thereof. They are made by reacting compounds (II) with compounds (III) or by reacting (III) with (IV) and acylating the 7-amino compound (V) obtained compounds (I) where n is 0, R<SP>1</SP> is 2-thienyl and R<SP>2</SP> is alkyl can, if desired, be decarboxylated to cleave the -COOR<SP>3</SP> group to form (I<SP>1</SP>), or (V) may be decarboxylated and the compound obtained thereafter acylated with a 2-theinylacetic acid derivative to give (I<SP>1</SP>). |
申请公布号 |
HU172045(B) |
申请公布日期 |
1978.05.28 |
申请号 |
HU1975ME01866 |
申请日期 |
1975.06.19 |
申请人 |
MEIJI SEIKA KAISHA,LTD,JP |
发明人 |
KAI,FUMIO,JP;SAITO,TOSHINORI,JP;SEKI,SHIGEO,JP;KAWASAKI,TOYOAKI,JP |
分类号 |
A61K31/545;A61K31/546;A61P31/04;C07D;C07D501/04;C07D501/24;C07D501/36;C07D501/40;C07D501/42;C07D501/46;C07D501/48;C07D501/54;C07D501/56;C07D501/60 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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