| 摘要 |
alpha -Aminoacyl cephalosporins represented by the formula HOH ¦ PARALLEL ¦ R-C-C-N ¦ NH2-O-R1 PARALLEL O ¦C=O ¦ O-R2 HOH ¦ PARALLEL ¦ R-C-C-N ¦ NH2-O-R1 PARALLEL O ¦C=O ¦ O-R2 wherein R is phenyl, substituted phenyl, thienyl or furyl, R1 is hydrogen, methyl, ethyl or 3-methyl-2-butenyl; and R2 is hydrogen or an ester forming group; are provided. When R1 is other than hydrogen and R2 is hydrogen the 3-cephem ethers provided are valuable orally effective antibiotics, especially 7-(D- alpha -phenylglycylamido)-3-methoxy-3-cephem-4-carboxylic acid. The 3-hydroxy cephalosporins (R1 = H, R2 = ester) are valuable intermediates. |
