| 摘要 |
<p>Cephalosporins of formula (I) and their pharmaceutically acceptable salts and esters are new (R = organic acylamino, Y = N-contg. 5-membered ring. n = 0 or 1. R1 and R2 are H or 1-6C alkyl. R3 and R4 are each 1-3C alkyl or together they complete a monocyclic ring). Also new are the intermediates of formulae (VI) and (IXA) (where Rx = H or a blocking gp. m = 0 or 1. The dotted line is a double bond at 2 or 3 posn.). Cpds. (I) are antibacterials for use in human or veterinary medicine and are administered in usual oral, topical or parenteral forms e.g. unit doses of 50-500 mg for an adult human dose of 0.1-3 g/day. They are pref. used together with clavulanic acid or its derivs. A typical cpd. is 7- D-alpha-(3-benzoyl-3-methylureido) phenylacetamido -3-(2-carbamoylmethyl-1,3,4-oxadiazol-5-ylthio) methylceph-3-em-4-carboxylic acid/.</p> |
