| 摘要 |
<p>New tricyclic ortho-fused heterocyclic compounds of formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="58" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein A is the group R or the group N
<Chemistry id="chema02" num="0002"><Image id="ia02" he="20" wi="66" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>in which R represents hydrogen, (C<Sub>1-4</Sub>) alkyl, phenyl or tolyl and R, may be (C<Sub>1-4</Sub>) alkyl, phenyl or tolyl, R<Sub>2</Sub> is selected from (C<Sub>1-4</Sub>) alkyl, (C<Sub>2-4</Sub>) alkanoylmethyl, carbo- (C<Sub>1-3</Sub>) alkoxymethyl, hydroxy (C<Sub>2-4</Sub>) alkyl, halo (C<Sub>2</Sub>.<Sub>4</Sub>) alkyl and a group
<Chemistry id="chema03" num="0003"><Image id="ia03" he="13" wi="33" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R<Sub>3</Sub> is an alkylene group from 2 to 4 carbon atoms and R. and R<Sub>s</Sub> independently represent hydrogen or (C<Sub>1-4</Sub>) alkyl or, taken together with the nitrogen atom, a fully hydrogenated 5 or 6 membered heterocyclic radical which may contain a further heteroatom selected from 0, N and S and be optionally substituted by a (C<Sub>1-4</Sub>) alkyl or phenyl group, or R<Sub>2</Sub> may represent nil, the dotted lines x and y may represent nil or additional bonds; with the proviso that, when the symbol R<Sub>2</Sub> linked to the oxygen atom is different from nil, x is an additional bond and y and the other symbol R<Sub>2</Sub> represent nil; with the further proviso that. when the symbol R<Sub>2</Sub> linked to the nitrogen atom is different from nil, y is an additional bond and x and the other symbol R<Sub>2</Sub>, represent nil; and salts therewith of pharmaceutically acceptable acids. The compounds possess antiinflammatory CNS-depressant and anti-anxiety utility.</p> |
