| 摘要 |
Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed. |
| 主权项 |
1. A method of treating a patient suffering from a disease chosen from the group consisting of psoriasis, multiple sclerosis, Huntington's disease, asthma, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, rheumatoid arthritis, Crohn's disease, ankylosing spondylitis, ulcerative colitis and psoriatic arthritis, comprising administering to a patient in need thereof a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein:
R1 is chosen from the group consisting of hydrogen, C1-6 alkyl, substituted C1-6 alkyl, C1-6 heteroalkyl, substituted C1-6 heteroalkyl, C3-12 cycloalkyl, substituted C3-12 cycloalkyl, C3-12 heterocycloalkyl, substituted C3-12 heterocycloalkyl, C5-10 aryl, substituted C5-10 aryl, C5-10 heteroaryl, and substituted C5-10 heteroaryl;R2 and R3 together with the carbon to which they are bonded form a ring chosen from the group consisting of C5-10 heteroaryl and substituted C5-10 heteroaryl; andX1 and X2 are independently chosen from the group consisting of a bond, C1-6 alkane-diyl, and and substituted C1-6 alkane-diyl;wherein each substituent group is independently chosen from the group consisting of halogen, —OH, —CN, —CF3, ═O, —NO2, benzyl, —C(O)NR212, —R21, —OR21, —C(O)R21, —C(O)OR21, —NR212, —NR21C(O)R21, and —O(O)R21, wherein each R21 is independently chosen from the group consisting of hydrogen, C1-6 alkyl, C1-6 heteroalkyl, C3-12 cycloalkyl, C5-10 aryl, C5-10 heteroaryl, and amino acid side chain. |
