Oxapenem derivatives, their preparation, their use, pharmaceutical compositions containing them, diverse initial compounds and their preparation.

摘要

Disclosed is a process for the production of a compound of the general formula I <CHEM> or a salt thereof, which comprises reacting a compound of the general formula II <CHEM> with a tervalent organophosphorus compound and, if desired, simultaneously or subsequently with a thiophilic agent as hereinbefore defined. Compounds (I) and (II), pharmaceutical compositions containing compounds (I) and the use of these compounds as beta -lactamase inhibitors and or as antibacterial agents are described. Also described are initial compounds (penicillins, acetidinones) and processes for their preparation.