FORFARANDE FOR FRAMSTELLNING AV BASISKT SUBSTITUERADE DERIVAT AV 4-HYDROXI-BENSIMIDAZOL

摘要

New 4-hydroxy-benzimidazole compounds of the formula: OH ¦O-CH2-CH-CH2-NH-R1 (I) wherein R1 is straight-chained or branched alkyl and R2 is hydrogen atom or lower alkyl AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; ARE OUTSTANDINGLY EFFECTIVE IN THE TREATMENT AND PROPHYLAXIS OF CARDIAC AND CIRCULATORY DISEASES, AND PROVIDE SUBSTANTIALLY GREATER MARGINS OF SAFETY THAN PRIOR ART ADRENERGIC beta -RECEPTOR INHIBITORS.