SOLVENT SYSTEM FOR ENHANCING THE SOLUBILITY OF PHARMACEUTICAL AGENTS

摘要

The invention is directed to a pharmaceutical composition comprising:
(a) naproxen sodium;
(b) lactic acid in an amount of from 0.2 to 1.0 mole equivalents per mole of the naproxen sodium;
(c) polyethylene glycol; and
(d) a solubilizer selected from glycerin, polyvinylpyrrolidone, propylene glycol, or combinations thereof. The compositions of the invention may be encapsulated in a softgel capsule.