Process for the production of cholecystokinin-pancreozymin C-terminal peptide amide sulfate esters

摘要

A novel process for the production of cholecystokininpancreozymin C-terminal peptide amide sulfate esters in a high yield and through a simple operation is described. A protected peptide amide is reacted with sulfur trioxide-pyridine complex and resulting protected piptide amide sulfate ester is then isolated in the form of its calcium salt. Thereafter, the protecting groups and calcium are removed. Sulfuric acid resulting from unreacted sulfur trioxide-pyridine complex may be precipitated and easily removed in the form of calcium sulfate.