Compounds and uses thereof for the modulation of hemoglobin

摘要

Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

主权项

1. A compound selected from the group consisting ofor an N oxide thereof wherein
each Y and Z is independently CR10R11, O, S, SO, SO2 or NR12; each R10 and R11 independently is hydrogen or C1-C3 alkyl, optionally substituted with halo, OH, or alkoxy, or CR10R11 is C═O; R12 is hydrogen or C1-C6 alkyl; provided that if one of Y and Z is O, S, SO, SO2, then the other is not CO, and provided that and Z are both not heteroatoms or oxidized forms thereof; x is 0, 1, or 2; R14 is C1-C6 alkyl, COR15, or COOR15;and R15 is optionally substituted C3-C6 alkyl, optionally substituted C5-C10 aryl, optionally substituted 5-10 membered heteroaryl or optionally substituted 4-10 membered heterocycle containing up to 5 ring heteroatoms, wherein the heteroatom is selected from the group consisting of O, N and/or S and/or oxidized forms of N and S.