| 主权项 |
1. A compound of formula (II): or a pharmaceutically acceptable salt thereof, wherein: D is —C(Rh)═; E is —C(Rh)═; Rg is hydrogen, halo, cyano, —C(R5)═C(R5)2, —C≡C—R5, —OR5, —SR6, —S(O)R6, —SO2R6, —SO2N(R4)2, —N(R4)2, —NR4C(O)R5, —NR4C(O)N(R4)2, —N(R4)C(═NR4)—N(R4)2, —N(R4)C(═NR4)—R6, —NR4CO2R6, —N(R4)SO2R6, —N(R4)SO2N(R4)2, —O—C(O)R5, —OCO2R6, —OC(O)N(R4)2, —C(O)R5, —CO2R5, —C(O)N(R4)2, —C(O)N(R4)—OR5, —C(O)N(R4)C(═NR4)—N(R4)2, —N(R4)C(═NR4)—N(R4)—C(O)R5, —C(═NR4)—N(R4)2, —C(═NR4)—OR5, —N(R4)—N(R4)2, —N (R4)—OR5, —C(═NR4)—N(R4)—OR5, —C(R6)═N—OR5, or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl; and each Rh independently is hydrogen, halo, —CN—, —OR5, —N(R4)2, —SR6, or an optionally substituted C1-4 aliphatic group; W is —CH2—, —CHF—, —CF2—, —CH(R1)—, —CF(R1)—, —NH—, —N(R1)—, —O—, —S—, or —NHC(O)—; R1 is C1-4 aliphatic or C1-4 fluoroaliphatic; X is —CH2—, —CHF—, —CF2—, —NH—, or —O—; Y is —O—, —S—, or —C(Rm)(Rn)—; Ra is hydrogen,
fluoro, —CN, —N3, —OR5, —N(R4)2, —NR4CO2R6, —NR4C(O)R5, —C(O)N(R4)2, —C(O) R5, —OC(O)N(R4)2, —OC(O)R5, —OCO2R6, or a C1-4 aliphatic or C1-4 fluoroaliphatic optionally substituted with one or two substituents independently selected from —OR5x, —N(R4x)(R4y), —CO2R5x, or —C(O)N(R4x)(R4y); or Ra and Rc together form a bond; Rb is hydrogen, fluoro, C1-4 aliphatic, or C1-4 fluoroaliphatic; Rc is hydrogen, fluoro, —CN, —N3, —OR5, —N(R4)2, —NR4CO2R6, —NR4C(O)R5, —C(O)N(R4)2, —C(O)R5, —OC(O)N(R4)2, —OC(O)R5, —OCO2R6, or a C1-4 aliphatic or C1-4 fluoroaliphatic optionally substituted with one or two substituents independently selected from —OR5x, —N(R4x)(R4y), —CO2R5x, or —C(O)N(R4x)(R4y); or Ra and Ro together form a bond; Rd is hydrogen, fluoro, C1-4 aliphatic, or C1-4 fluoroaliphatic; Re is hydrogen, or C1-4 aliphatic; or Re, taken together with one Rf and the intervening carbon atoms, forms a 3- to 6-membered spirocyclic ring; or Re, taken together with Rm and the intervening carbon atoms, forms a fused cyclopropane ring, which is optionally substituted with one or two substituents independently selected from fluoro or C1-4 aliphatic; Re′ is hydrogen or C1-4 aliphatic; or Re′, taken together with Rm and the intervening carbon atoms, forms a fused cyclopropane ring, which is optionally substituted with one or two substituents independently selected from fluoro or C1-4 aliphatic; each Rf is independently hydrogen, fluoro, C1-4 aliphatic, or C1-4 fluoroaliphatic; or two Rf taken together form ═O; or two Rf, taken together with the carbon atom to which they are attached, form a 3- to 6-membered carbocyclic ring; or one Rf, taken together with Re and the intervening carbon atoms, forms a 3- to 6-membered spirocyclic ring; Rm is hydrogen, fluoro, —N(R4)2, or an optionally substituted C1-4 aliphatic group; or Rm and Rn together form ═O or ═C(R5)2; or Rm and Re, taken together with the intervening carbon atoms, form a fused cyclopropane ring, which is optionally substituted with one or two substituents independently selected from fluoro or C1-4 aliphatic; or Rm and Re′, taken together with the intervening carbon atoms, form a fused cyclopropane ring, which is optionally substituted with one or two substituents independently selected from fluoro or C1-4 aliphatic; Rn is hydrogen, fluoro, or an optionally substituted C1-4 aliphatic group; or Rm and Rn together form ═O or ═C(R5)2; each R4 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; or two R4 on the same nitrogen atom, taken together with the nitrogen atom, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms independently selected from N, O, and S; R4x is hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, or C6-10 ar(C1-4)alkyl, the aryl portion of which may be optionally substituted; R4y is hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, C6-10 ar(C1-4)alkyl, the aryl portion of which may be optionally substituted, or an optionally substituted 5- or 6-membered aryl, heteroaryl, or heterocyclyl ring; or R4x and R4y, taken together with the nitrogen atom to which they are attached, form an optionally substituted 4- to 8-membered heterocyclyl ring having, in addition to the nitrogen atom, 0-2 ring heteroatoms independently selected from N, O, and S; and each R5 independently is hydrogen or an optionally substituted aliphatic, aryl, heteroaryl, or heterocyclyl group; each R5x independently is hydrogen, C1-4 alkyl, C1-4 fluoroalkyl, or an optionally substituted C6-10 aryl or C6-10 ar(C1-4)alkyl; each R6 independently is an optionally substituted aliphatic, aryl, or heteroaryl group; and m is 1, 2, or 3. |
