Alkyl-substituted polymers having enhanced albumin affinity.

摘要

Methods and compositions are provided for selectively enhancing the affinity of albumin for the surface of polymeric materials. Reactive alkyl chains having C8-C30 residues are covalently attached directly to polymeric materials such as polyamides, polyesters, polyacrylamides, and polyurethanes. Reactive alkyl compounds include alkyl halides, alkyl sulfonates, alkyl isocyanates, and alkyl amines. Alternatively, intermediate bifunctional arms, e.g. toluene-diisocyanate, can be used to link the alkyl chains to the meric polymer precursors which, following polymerization, are available for albumin binding without postpolymerization modification. The resulting compositions when implemented in conjunction with blood products selectively enhance albumin surface affinity-binding to the exclusion of other blood components, and subsequent thrombus formation is prevented.