| 摘要 |
<p>The invention provides pharmaceutically active agents of the structural formula
<Chemistry id="chema01" num="0001"><Image id="ia01" he="19" wi="84" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein n is 1 or2;
<UnorderedLists id="ula01" listStyle="none"><ListItem>X is Z if n is 1 and X is CH<Sub>2</Sub>Y, CH<Sub>2</Sub>0H or OH if n is 2;</ListItem><ListItem>Y is OH if n is 1 and if n is 2, one of the radicals Y is Z and all other radicals Y are OH;
<Chemistry id="chema02" num="0002"><Image id="ia02" he="12" wi="44" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry></ListItem><ListItem>R<Sub>11</Sub> is a C<Sub>3</Sub>-C<Sub>10</Sub> linear or branched alkyl;</ListItem><ListItem>a C<Sub>3</Sub>-C<Sub>5</Sub> linear or branched alkenyl or alkynyl;</ListItem><ListItem>a C2-C4 linear or branched alkyl substituted by C<Sub>1</Sub>-C<Sub>4</Sub> alkoxy, methoxymethoxy, methoxyethoxy, or hydroxyethoxy radicals;</ListItem><ListItem>C<Sub>3-8</Sub> cycloalkyl;</ListItem><ListItem>C<Sub>1</Sub>-<Sub>3</Sub> alkyl substituted with C<Sub>3-8</Sub> cycloalkyl groups; benzyl;</ListItem><ListItem>benzyl having 1 to 3 substituents selected from the group consisting of C<Sub>1-4</Sub> alkyl, C<Sub>1-4</Sub> alkoxy and cyclopropyl;</ListItem><ListItem>phenethyl;</ListItem><ListItem>tetrahydrofurfuryl, furfuryl;</ListItem><ListItem>morpholinoethyl, morpholinopropyl;</ListItem><ListItem>piperidinoethyl; and</ListItem><ListItem>R<Sub>12</Sub> is a C<Sub>1</Sub>-C<Sub>10</Sub> linear or branched alkyl;</ListItem><ListItem>C<Sub>3</Sub>-C<Sub>5</Sub> linear or branched alkenyl or alkynyl;</ListItem><ListItem>C<Sub>1-6</Sub> hydroxyalkyl;</ListItem><ListItem>C<Sub>2</Sub>-<Sub>4</Sub> linear or branched alkyl substituted by C<Sub>1-4</Sub> alkoxy or C<Sub>1-4</Sub> hydroxyalkoxy;</ListItem><ListItem>C<Sub>3-8</Sub> cycloalkyl;</ListItem><ListItem>C<Sub>1</Sub>-<Sub>3</Sub> alkyl substituted by a C<Sub>3</Sub>-<Sub>8</Sub> cycloalkyl radical;</ListItem><ListItem>benzyl, chlorobenzyl;</ListItem><ListItem>benzyl having 1 to 3 substituents selected from the group consisting of C<Sub>1-4</Sub> alkyl and C<Sub>1-4</Sub> alkoxy;</ListItem><ListItem>tetrahydrofurfuryl;</ListItem><ListItem>furfuryl;</ListItem><ListItem>morpholino;</ListItem><ListItem>morpholinoethyl;</ListItem><ListItem>morpholinopropyl;</ListItem><ListItem>thiophen-2-yl-methyl;</ListItem><ListItem>pyridylethyl; and</ListItem><ListItem>piperidinoethyl.</ListItem></UnorderedLists></p> |
