| 摘要 |
A method for regulating the bone metabolism of a warm-blooded animal, which comprises administering pharmaceutically effective amounts of 1 alpha , 24-dihydroxycholecalciferol (1 alpha , 24-DHCC) and 24,25-dihydroxycholecalciferol (24,25-DHCC) to said warm-blooded animal, and a pharmaceutical composition comprising 1 alpha ,24-DHCC, 24,25-DHCC and a pharmaceutically acceptable carrier. According to the invention, a condition of abnormal bone metabolism requiring long-term therapy, such as osteoporosis, can be safely treated by administering 1 alpha , 24-DHCC and 24,25-DHCC over a long period of time because no substantial adverse effect of 1 alpha , 24-DHCC on the metabolis of 24,25-DHCC is observed.
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