Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions.

摘要

6,11-dihydrodibenz[b,e]oxepins of formula: in which R2 and R3 are hydrogen, halogen, CF3 or various N-, O- or S- attached substituents; R4 is hydrogen or various N-, O- or S- attached substituents and R5 is hydrogen or C1-4 alkyl, or R4 and R5 are together oxo, methylene or aryl-substituted methylene; and R1 is 5-tetrazoyl, 3-hydroxy-1,2,5-thiadiazol-4-yl, 4-hydroxy- DELTA <3>-pyrroline-2,5-dione-3-yl or -@-R6 where R6 is certain O- or N-attached residues, including hydroxy and 2-imino-3-methylthiazolidine, are useful in treating disease, particularly allergic diseases such as asthma. To this end they may be made up into pharmaceutical compositions. Certain of the compounds are novel. The compounds are made by various routes, depending on the nature of the substituents.