发明名称 PROCESS FOR PREPARING DIBENZO(A,D)CYCLOOCTEN-5,12-(AND 6,12)-IMINES
摘要 Title compds. I(R,R1,R2= H, lower alkyl, alkenyl, lower cycloalkyl; R3,R3= H, halogen, lower alkoxy, CN, COOH, OH; if m=1 or O, Q = CH2, -CH2-CH2- or -CH=CH-, resp.) useful as tranquilizer and muscle relaxant, were prepd. by the reaction of compds. II (Y = H, acetyl; -(R2 -H) = lower alkylene, alkenylene) with strong base at 150↿-250≦̸C or with lithium alkyl in ether. Thus, a mixt. of 12-bromo-13-methyl-5,6,7,12-tetrahydrodibenzo[a,d cyclooctene-6,12-imine, CH3,ONa, and MeOH was refluxed to give 12-methoxy-13-methyl-5,6,7,12-tetrahydrodibenzo[a,d cyclooctene-6,12-imine.
申请公布号 KR830000255(A) 申请公布日期 1983.02.25
申请号 KR19780002840 申请日期 1978.09.18
申请人 MERCK & CO INC 发明人 EVANS BEN EDWARD;ANDERSON PAUL STANLEY;CHRISTY MARCIA ELIZABETH;REMY DAVID CARROLL;KARADY SANDOR
分类号 C07D487/08;(IPC1-7):C07D487/08 主分类号 C07D487/08
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