发明名称 |
Process for preparing a dihydropyridine derivative |
摘要 |
Dihydropyridines of formula <IMAGE> where R6 is lower alkyl and R5 is lower alkyl or aryl (lower)alkyl are prepared by a novel process from sodium or potassium salts of 1-substituted-1,6-dihydro-5-hydroxy-3[2H]-pyridones. The dihydropyridines are useful as intermediates for pharmacologically active 1-optionally substituted-3-phenyl or substituted phenylpiperidin-5-ols and esters. Some of the piperidinols and esters are novel; those where the 1-substituent is aryl(lower)alkyl are intermediates, those where the 1-substituent is cycloalkyl(lower)alkyl are analgesics or antidepressants and those in which the 1-position is unsubstituted are anti-secretory agents.
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申请公布号 |
US4387230(A) |
申请公布日期 |
1983.06.07 |
申请号 |
US19810294678 |
申请日期 |
1981.08.20 |
申请人 |
JOHN WYETH AND BROTHER LIMITED |
发明人 |
WHITE, ALAN C.;SHEPHERD, ROBIN G. |
分类号 |
C07D211/42;C07D211/74;C07D211/86;(IPC1-7):C07D211/02 |
主分类号 |
C07D211/42 |
代理机构 |
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