TETRAHYDROISOQUINOLINE COMPOUNDS, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

A compound of the formula: (I) wherein R1 is hydrogen or methyl, is prepared by condensing a compound of the formula: (II) wherein R2 is alkyl, aryl or aralkyl and R1 is same as above, or a reactive derivative thereof with 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid or an ester thereof to give a compound of the formula: (IV) wherein R3 is an ester residue and R1 and R2 are same as above, followed by hydrolysis or ammonolysis of said compound (IV). The compound (I) is useful as a diagnostic or therapeutic agent for angiotensin-related hypertension.