| 摘要 |
A solid base material for skin external application has a breaking strength high enough to be used for a stick-shaped base material and the like. A solid base material for skin external application has: a surfactant; water; and a lipid peptide compound including at least one of compounds of Formula (1) and the analogous thereof or pharmaceutically usable salts of the compound:;;wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom, or a C1-4 alkyl group that may have a C1 or C2 branched chain; R3 is a —(CH2)n—X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms. |
| 主权项 |
1. A solid base material for skin external application, the solid base material comprising:
a surfactant; water; and a lipid peptide compound including at least one of compounds of Formulae (1) to (3) or pharmaceutically usable salts of the compound:(where R1 is a C9-23 aliphatic group; R2 is a hydrogen atom, or a C1-4 alkyl group that may have a C1 or C2 branched chain; and R3 is a —(CH2)n—X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms)(where R4 is a C9-23 aliphatic group; R5 to R7 are each independently a hydrogen atom, a C1-4 alkyl group that may have a C1 or C2 branched chain, or a —(CH2)n—X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms)(where R8 is a C9-23 aliphatic group; R9 to R12 are each independently a hydrogen atom, a C1-4 alkyl group that may have a C1 or C2 branched chain, or a —(CH2)n—X group, where n is a number from 1 to 4, and X is amino group, guanidino group, —CONH2 group, or a 5-membered or 6-membered ring that may have 1 to 3 nitrogen atoms or a condensed heterocycle composed of 5-membered and 6-membered rings that may have 1 to 3 nitrogen atoms). |
