Pyrimidone compounds, their preparation, and pharmaceutical compositions containing them.

摘要

Novel pyrimidones of the formula I and salts thereof are gastric acid secretion inhibitors and some have other medical utility: <CHEM> wherein R1 represents a hydrogen atom, a C1 to C10 alkyl group, a C1 to C5 alkenyl group, a C1 to C5 alkinyl group, a phenyl group, a cycloalkylmethyl group, an unsubstituted or substituted aralkyl group, or the group <CHEM> wherein A represents a C1 to C5 alkylene group and R3 and R4 are the same or different C1 to C5 alkyl groups or combine to form with the adjacent nitrogen atom a piperidine or pyrrolidine ring; R2 represents a hydrogen atom, a C1 to C5 alkyl group or a trifluoromethyl group: Y represents a heterocyclic group of the formula: <CHEM> wherein R represents a hydrogen atom or a C1 to C5 alkyl group: B represents an oxygen atom or a sulfur atom; m represents zero or an integer of 1 to 3; and n represents an integer of 1 to 3. Methods and novel intermediates for their preparation are disclosed, as well as medicaments containing them and medical treatments using them.