THERAPEUTIC COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND PROCESS FOR THEIR PREPARATION

摘要

The invention relates to new compositions of poorly soluble or water insoluble drugs and to compositions of relatively soluble drugs which have a tendency to agglomerate or crystallise in storage or after formulation into pharmaceutical dosage form. The new compositions provide higher dissolution rates of said drugs in vitro and increased bioavailability. The compositions of this invention comprise such poorly soluble, water insoluble or relatively soluble drugs, a non-toxic water soluble poiymer and a wetting agent. A process for preparing the compositions is also disclosed. Compositions containing the known anti-fungal griseofulvin illustrate the invention.