| 发明名称 |
ENHANCING THE IN-VIVO EFFICIENCY OF PARTICLE DELIVERY THROUGH NON-COVALENT INTERACTION WITH RED BLOOD CELL SURFACE PROTEINS |
| 摘要 |
The present invention relates to the production of modified microscale and nanoscale particles that have enhanced in vivo delivery characteristics. The resultant particles can be used in any of a number of applications including informatics, detection, diagnosis, imaging, and/or therapeutics. Further, the modified particles of the present invention have enhanced circulation half time and elimination rate constant characteristics, and enhanced biodistribution. |
| 申请公布号 |
US2016367683(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201514743717 |
申请日期 |
2015.06.18 |
| 申请人 |
South Dakota State University |
发明人 |
Tummala Hemachand;Muley Pratik |
| 分类号 |
A61K47/48;A61K9/00;A61K35/14;A61K49/00 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1: A method of enhancing efficiency of in vivo particle delivery comprising:
conjugating a molecule to a particle to produce a surface modified particle, wherein said molecule mediates binding to a protein, peptide, lipid or carbohydrate on the surface of a blood cell. |
| 地址 |
Brookings SD US |
