发明名称 |
PROCESS FOR PREPARING 3-ALLYL-7,8-DIHYDROXY-6-HALO-1-(4-HYDROXYPHENYL)-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE DERIVATIVES |
摘要 |
<p>The invention provides 3-allyl-7,8-dihydroxy-6-halo-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine derivatives, O-alkanoyl esters thereof and pharmaceutically acceptable acid addition salts of these compounds. These compounds have a unique cardiovascular effect in that they are potent renal vasodilators and also induce bradycardia. The invention therefore includes pharmaceutical compositions containing such compounds. The compounds of the invention can be prepared by reacting an appropriate ether of the desired compound in which all three hydroxy groups are etherified, with an ether cleaving agent, with optional subsequent O-acylation and/or salt formation.</p> |
申请公布号 |
IN154373(B) |
申请公布日期 |
1984.10.20 |
申请号 |
IN1980DE35919 |
申请日期 |
1980.05.16 |
申请人 |
SMITHKLINE BECKMAN CORPORATION |
发明人 |
WEINSTOCK JOSEPH |
分类号 |
A61K31/55;A61P9/08;A61P9/10;C07D223/16;(IPC1-7):C07D41/00 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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