| 摘要 |
<p>Compounds of formula (I) and pharmaceutically acceptable salts thereof: <CHEM> wherein: G together with the two carbon atoms to which it is bonded is a thieno moiety; R1 is phenyl optionally substituted by one or more C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, hydroxy, C2-7 alkanoyl, halo, trifuluoromethyl, nitro, amino optionally substituted by one or two C1-6 alkyl groups or by C2-7 alkanoyl, cyano, carbamoyl or carboxy groups; or pyridyl optionally substituted by C1-8 alkyl or halo; R6 is hydrogen, C1-6 alkyl or phenyl optionally substituted as defined hereinbefore for R1 when phenyl; R8 is hydrogen, one of the optional substituents recited hereinbefore for R1 when phenyl or phenyl optionally substituted as defined hereinbefore for R1 when phenyl; and either R2 is hydrogen, or C1-6 alkyl optionally substituted by hydroxy, amino disubstituted by C1-6 alkyl, or phenyl optionally substituted as defined hereinbefore for R1 when phenyl; R3 and R4 together represent a bond; R5 and R7 together represent a bond; and R9 is hydrogen and R10 is hydroxy, C1-6 alkoxy or amino optionally substituted by one or two independently selected C1-6 alkyl groups or by phenyl optionally substituted as defined hereinbefore for R1 when phenyl, or R9 and R10 together represent a bond; or R2 and R3 together represent a bond; R4 and R5 together represent a bond; and R7 is hydrogen, C1-6 alkyl optionally substituted by hydroxy, amino disubstituted by c1-6 alkyl, or phenyl optionally substituted as defined hereinbefore for R1 when phenyl; and R9 and R10 together represent a bond, having pharmacological activity, a process and intermediates for their preparation, compositions containing them and their use in the treatment of mammals.</p> |
