| 摘要 |
Imidazo[1,2-a]pyridine derivatives of the general formula: <IMAGE> wherein n represents 2, 3 or 4, Y represents a hydrogen or halogen atom or a C1-4 alkyl radical, Z represents a naphthyl radical; a phenyl radical <IMAGE> in which X1 and X2 independently of one another each represent a hydrogen or halogen atom, a C1-4 alkoxy radical, a C1-6 alkyl radical or the group -CF3, CH3S-, CH3SO2- or -NO2; or a thien-2-yl, furan-2-yl or pyridine-2-yl radical optionally carrying a halogen atom or the methyl or ethyl radical in the 5-position, and R represents the hydroxy radical, or a group -NR1R2 in which R1 and R2 independently of one another each represent a hydrogen atom; a straight- or branched-chain C1-5 alkyl radical optionally carrying one or more halogen atoms, a hydroxy radical, a group -N(C1-4 alkyl)2, a carbamoyl radical or a C1-4 alkoxy radical; the allyl radical; the propargyl radical; a C3-6 cycloalkyl radical; the benzyl radical; or the phenyl radical; or alternatively -NR1R2 together represent a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula <IMAGE> in which X is O, S, CHOR' or NR'', R' being a hydrogen atom or the benzyl radical and R'' being a hydrogen atom, a C1-4 alkyl radical or the phenyl radical optionally carrying a methoxy radical or a halogen atom, are new compounds. They are therapeutically useful as they possess anxiolytic, antianoxic, sleep-inducing, hypnotic and anticonvulsant properties.
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