发明名称 |
PHARMACEUTICAL COMPOSITIONS OF METABOTROPIC GLUTAMATE 5 RECEPTOR (MGLU5) ANTAGONISTS 5(MGLU5) |
摘要 |
Pharmaceutical compositions of metabotropic glutamate 5 receptor (mGlu5) antagonists or a pharmacologically acceptable salt thereof are disclosed. The compositions contain the therapeutic active compound with non-ionic polymer and ionic polymer, binder and fillers in either matrix pellet, matrix tablet or coated pellets. The compositions provide a pH-independent in vitro release profile with NMT 70% in one hour, NMT 85% in 4 hour, and NLT 80% in 8 hours. The compositions are useful for the treatment of CNS disorders, such as Treatment-Resistant Depression (TRD) and Fragile X Syndrome. |
申请公布号 |
HK1181654(A1) |
申请公布日期 |
2016.10.07 |
申请号 |
HK20130108973 |
申请日期 |
2013.08.01 |
申请人 |
F.HOFFMANN LA ROCHE AG |
发明人 |
CHATTERJI, Ashish;HUANG, Jingjun;KOENNINGS, Stephanie;LINDENSTRUTH, Kai;SANDHU, Harpreet K. K;SHAH, Navnit Hargovindas |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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