Non-invasive bioreactor monitoring

摘要

A pair or receptacles capable of housing an emitter probe and a detector probe installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media.

主权项

1. A device for non-invasive, non-contact monitoring of a nutrient media in a bioreactor comprised of a container with a top surface, a bottom surface, and an inner volume capable of holding the nutrient media, the device comprising:
at least one pair of receptacles suitable for housing probes, the receptacles configured for hermetically sealing the probes from the nutrient media; and each comprising one open end in fluid communication with the outside of the bioreactor via the bottom surface and one sealed end; an emitter probe capable of producing an electromagnetic or acoustic signal disposed in a first receptacle of the at least one pair of receptacles; a detector probe capable of detecting an electromagnetic or acoustic signal disposed in a second receptacle of the at least one pair of receptacles; wherein the distance between the first receptacle and the second receptacle can be varied by adjusting the first receptacle and the second receptacle up and down, or sideways, wherein the distance between the receptacles represents the depth of the nutrient media monitored; and an electronic means for converting a signal received from the detector probe into physical and chemical properties of the nutrient media.