Gastrokinetic and antiemetic n-(1-substituted-4,5-dihydro-1h-pyrazol-4-yl)benzamides.

摘要

N-(1-Substituted-4,5-dihydro-IH-pyrazol-4-yl) benzamides of general formula I.
<Chemistry id="chema01" num="0001"><Image id="ia01" he="13" wi="80" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein R is loweralkyl, cycloalkyl or phenyl-loweralkyl and R, is hydroxy, cyano, nitro, amino, methylamino, dimethylamino, halo, trifluoromethyl, loweralkyl, loweralkoxy, sulphamoyl or acetamido, and when n is more than 1 up to 3, R, can be the same or different, have gastrokinetic and anti- emetic utility in animals. The compounds can be prepared by oxidation of 1,2-disubstituted-N-(4-pyrazolidinyl) benzamides with a metal hypochlorite.