Dihydropyridines.

摘要

Compounds of the formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="73" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry><UnorderedLists id="ula01" listStyle="none"><ListItem>where R is an optionally substituted aryl or heteroaryl group;</ListItem><ListItem>R<Sup>1</Sup> and R are each independently C<Sub>1</Sub>-C<Sub>4</Sub> alkyl or 2-methoxyethyl; and Y is -(CH<Sub>2</Sub>)<Sub>n</Sub>- where n is 2, 3 or 4, -CH<Sub>2</Sub>CH(CH<Sub>3</Sub>)-or -CH<Sub>2</Sub>C(CH<Sub>3</Sub>)<Sub>2</Sub>-; and their pharmaceutically acceptable salts.</ListItem></UnorderedLists>

The compounds have utility as anti-ischaemic and antihypertensive agents and as synthetic intermediates to other dihydropyridine calcium antagonists.