5,6,7,-Trinor-4,8-inter-m-phenylene PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them

摘要

Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-17- alpha -methyl-20-homo PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentan or-15-phenyl PGI2. They are useful in treatment of ulcers, thrombii and hypertension for example.