| 发明名称 |
TRANSGENIC TRANSCHROMOSOMAL RODENTS FOR MAKING HUMAN ANTIBODIES |
| 摘要 |
The present invention provides novel transgenic nonhuman mammals capable of producing human sequence antibodies, as well as methods of producing and using these antibodies. |
| 申请公布号 |
US2016324131(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201615218202 |
申请日期 |
2016.07.25 |
| 申请人 |
KYOWA HAKKO KIRIN CO., LTD. ;E.R. SQUIBB & SONS, L.L.C. |
发明人 |
Tomizuka Kazuma;Ishida Isao;Lonberg Nils;Halk Edward L. |
| 分类号 |
A01K67/027;C12N15/85;C07K16/18;C07K16/00;C07K16/28;C07K16/24;C12Q1/68;C12P21/00 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A transgenic mouse comprising two human immunoglobulin loci, wherein one human immunoglobulin locus is a human heavy chain locus located on an autonomous transchromosome comprising a fragment of human chromosome 14 having a human chromosome 14 centromere, and the other human immunoglobulin locus is a human light chain locus transgene integrated into the mouse genome. |
| 地址 |
Tokyo JP |
