POLYPEPTIDES WITH AN .alpha.-AMYLASE-INHIBITING ACTION, A PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PRODUCTS

摘要

Cyclic polypeptides of the formula I < IMG > I in which z: represents Gln, Asn or Met; S: represents Ser or Thr; Y: represents Phe, Tyr or Asn and; AS: represents a polypeptide chain of 5 to 25 naturally occurring amino acids, which can in turn be substituted by further naturally occurring amino acids or peptide chains, excluding the .alpha.-amylase inactivator Tendamistat (HOE 467) and the .alpha.-amylase inhibitor isolated from the culture filtrate of Streptomyces violaceoruber ATCC 31209. The compounds have an .alpha.-amylase-inhibiting action.